• Qian Q, Li M, Zhang Z, Davis SW, Rahmouni K, Norris AW, Cao H, Ding WX, Hotamisligil GS, Ling Yang*.Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression. Cell Metab. 2024 May 3:S1550-4131(24)00134-7. doi: 10.1016/j.cmet.2024.04.014. Epub ahead of print. PMID: 38718793.
  • Sebag SC, Qian Q, Upara C, Ding Q, Cao H, Hong L, Ling Yang*. A Medium Chain Fatty Acid, 6-hydroxyhexanoic acid (6-HHA), Protects Against Obesity and Insulin Resistance. bioRxiv. 2023 Jul 20;. doi: 10.1101/2023.07.19.549684. PMID: 37502899; Accepted in APSB.
  • Mark Li, Roger R. Berton, Qingwen Qian, J. Alan Maschek, Biyi Chen, Elizabeth Barroso, Adam J. Rauckhorst, Thomas S. Griffith, Eric B. Taylor, James E. Cox, Vladimir P. Badovinac, Gökhan S. Hotamisligil, Long-Sheng Song, Ling Yang*. Hepatic IRE1 Protects Against Septic Cardiac Failure. bioRxiv 2023; doi: https://doi.org/10.1101/2023.03.14.532202.
  • Qingwen Qian, Mark Li, Zeyuan Zhang, Shannon Davis, Kama Rahmouni, Andrew Norris, Huojun Cao, Wen-xing Ding, Ling Yang*. Disruption of Pituitary-Liver UPR Interaction Contributes to NAFLD. bioRxiv, doi: https://doi.org/10.1101/2022.07.06.498610.
  • Mark Li, Jinxi Wang, Biyi Chen, Qingwen Qian, Zeyuan Zhang, Yuan Zhang, Duane D. Hall, E. Dale Abel, Long-Sheng Song, Ling Yang*. Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure. 2023, bioRxiv, doi: https://doi.org/10.1101/2022.07.03.498477.
  • Ma X, Manley S, Qian H, Li Y, Zhang C, Li K, Ding B, Guo F, Chen A, Zhang X, Liu M, Hao M, Kugler B, Morris EM, Thyfault J, Ling Yang, Sesaki H, Ni HM, McBride H, Ding WX. Mitochondria-lysosome-related organelles mediate mitochondrial clearance during cellular dedifferentiation. Cell Rep. 2023 PMID: 37862166.
  • Xiaojuan Chao, Shaogui Wang, Ling Yang, Hong-Min Ni, and Wen-Xing Ding. Trehalose Activates Hepatic TFEB but Fails to Ameliorate Alcohol-Impaired TFEB and Liver Injury in Mice. Alcoholism: Clinical and Experimental Research. 2021, Sep 5, PMID: 34486131.
  • Shaogui Wang, Xiaojuan Chao, Xiaoxiao Jiang, Tiantian Wang, Yssa Rodriguez, Ling Yang, Pal Pacher, Hong-Min Ni, and Wen-Xing Ding. Loss of Acinar Cell VMP1 Trigger Spontaneous Pancreatitis in Mice. Autophagy, 2021, Oct 28:1-11. doi: 10.1080/15548627.2021.1990672. PMID: 34709991.
  • Mark Li, Ling Yang*. Chapter 12: Autophagy in the liver, “Autophagy in Health and Disease 2nd ". Elsevier. 2021, September 22, ISBN:978012220030.
  • Qian H, Chao X, Williams J, Fulte S, Li T, Yang L, Ding WX. Autophagy in liver diseases: A review. Mol Aspects Med. 2021 Jun 10;:100973. doi: 10.1016/j.mam.2021.100973. [Epub ahead of print] PubMed PMID: 34120768.
  • Krongbaramee T, Zhu M, Qian Q, Zhang Z, Eliason S, Shu Y, Qian F, Akkouch A, Su D, Amendt BA, Yang L, Hong L. Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice. Mol Ther Nucleic Acids. 2021 Mar 5;23:1204-1216. doi: 10.1016/j.omtn.2021.01.030. eCollection 2021 Mar 5. PubMed PMID: 33664998; PubMed Central PMCID: PMC7899952.
  • Sebag SC, Zhang Z, Qian Q, Li M, Harata M, Li W, Zhu Z, Zingman L, Liu L, Lira VA, Potthoff MJ, Bartelt A, Yang L. ADH5 Maintains Metabolic Homeostasis in Brown Adipose Tissue. Cell Reports, 2021, Accepted.
  • Zhang Z#, Qian Q#, Li M, Shao F, Ding WX, Lira V, Chen SX, Sebag SC, Hotamisligil GS, Cao HJ, Ling Yang*. The Unfolded Protein Response Regulates Hepatic Autophagy by sXBP1-mediated Activation of TFEB. Autophagy, 2020 Jul 15;:1-15. doi: 10.1080/15548627.2020.1788889.
  • Mark Li#, Fan Shao#, Qingwen Qian, Wenjie Yu, Zeyuan Zhang, Biyi Chen, Dan Su, Yuwei Guo, An-Vi Phan, Long-sheng Song, Samuel B. Stephens, Julien Sebag, Yumi Imai, Ling Yang*, Huojun Cao*. A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells.  Mol Ther Nucleic Acids., 2021 Jul, 16;26:307-320. *Corresponding author.
  • Qingwen Qian#, Zeyuan Zhang#, Mark Li, Kalie Savage, Dechun Cheng, Adam J. Rauckhorst, James A. Ankrum, Eric B. Taylor, Wen-xing Ding, Yi Xiao, Huo-jun Cao, and Ling Yang*. Hepatic lysosomal iNOS activity impairs autophagy in obesity. Cellular and Molecular Gastroenterology and Hepatology. 2019, 8:1, 95-110. # Equal contribution. *Corresponding author
  • Jie-Mei Wang, Yining Qiu, Zhao Yang, Hyunbae Kim,  Qingwen Qian,  Qinghua Sun,  Chunbin Zhang,  Lei Yin,  Deyu Fang,  Sung Hong Back, Randal J. Kaufman, Ling Yang*, Kezhong Zhang*. IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Sci Signal. 2018 May 15;11(530). pii: eaao4617. doi: 10.1126/scisignal.aao4617. PMID: 29764990 * Corresponding author
  • Qian Q, Zhang Z, Orwig A, Chen S, Ding WX, Xu Y, Kunz RC, Lind NRL, Stamler JS, Yang L. S-nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy. Diabetes. 2017 Oct 26. pii: db170223. doi: 10.2337/db17-0223. [Epub ahead of print] PMID: 29074597
  • Nicholas R.L. Lind, Qingwen Qian, Ling Yang. ER stress and autophagy in obesity and nonalcoholic fatty liver disease. Current Pathology Reports, 2017, 5:289-299.
  • Ling Yang, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Long-Term calorie restriction enhances cellular quality-control processes in human skeletal muscle. Cell Rep., 2016 26;14(3):422-8. PMID: 26774472
  • Ling Yang, Ediz S. Calay, Jason Fan, Alessandro Arduini, Ryan C. Kunz, Steven P. Gygi, Abdullah Yalcin, Suneng Fu, Gökhan S. Hotamisligil. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science, 2015, 349:500-506. PMID: 26228140 
  • Gregor MF, Misch ES, Ling Yang, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS. The Role of Adipocyte XBP1 in Metabolic Regulation during Lactation. Cell Rep., 2013, 30;3(5):1430-9. PMID: 23623498
  • Henrik ten Freyhaus, Ediz Calay, Sara N. Vallerie, Abdullah Yalcin, Ling Yang, Fahri Saatcioglu and Gökhan S. Hotamisligil. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metabolism, 2012, 16:81-89. PMID: 22704678
  • Suneng Fu, Ling Yang, Ping Li, Oliver Hofman, Lee Dicker, Winston Hide, Xihong Lin, Steven M. Watkins, Alexander Ivanov, Gökhan S. Hotamisligil. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature, 2011, 473: 528–531. PMID: 21532591 
  • Kars M, Yang Ling, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes, 2010, 59(8):1899-905. PMID: 20522594
  • Ling Yang, Ping Li, Suneng Fu, Calay ES, GS Hotamisligil. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism, 2010, 11(6):467-78. PMID: 20519119
  • Margaret Gregor*, Ling Yang*, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic Reticulum Stress is Reduced in Tissues of Obese Subject after Weight Loss. Diabetes, 2009, 58(3):693-700.  * equal contribution. PMID: 19066313 
  • Ling Yang, Gökhan Hotamisligil. Stressing the Brain, Fattening the Body. Cell, 2008, 135(1), 20-22. PMID: 18854151

  1. Qian Q, Li M, Zhang Z, Davis SW, Rahmouni K, Norris AW, Cao H, Ding WX, Hotamisligil GS, Ling Yang*.Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression. Cell Metab. 2024 May 3:S1550-4131(24)00134-7. doi: 10.1016/j.cmet.2024.04.014. Epub ahead of print. PMID: 38718793.